The Twilight actress, her unnamed boyfriend and brother were asleep when fire broke out on the living room sofa, according to TMZ.
Three people were treated for minor injuries, with other reports of two people suffering burns and receiving hospital treatment, although identities are not clear at this stage.
It is unclear if Greene’s unnamed boyfriend is Reese Witherspoon’s ex-husband Ryan Phillippe, 38. The pair became the subject of romance rumours this week after being photographed leaving Hollywood’s Vignette Lounge on Wednesday.
Emergency crews: The heart of Hollywood was brought to a standstill today when Ashley Greene's third-floor apartment at the former home of screen legend Marylin Monroe caught fire
Gutted: A view inside Greene's apartment. The actress, the unnamed boyfriend and brother were in the apartment when fire broke out this morning before fleeing the scene. One of the star's dogs perished in the blaze
One of Greene's dogs perished in the blaze and was found dead under the bed, according to a resident who spoke to the website. A second dog was taken by Animal Control to be checked out.
The 26-year-old actress fled the apartment with her brother and boyfriend. The two men tried to go back to save the dogs but were unable to re-enter, TMZ reports. Green was later spotted at the scene covered in soot.
Several residents tried to tackle the blaze with fire extinguishers before at least 10 fire trucks screeched to the scene of the historic A-list complex once lived in by Marilyn Monroe. After being dispatched at 9.50am, the fire was extinguished just after 10am.
'Aggressive response': At least 10 fire trucks and 55 firefighters descended on the scene at the Granville Towers apartments on Crescent Heights Boulevard. Three people suffered minor injuries, with other reports of two people being treated for burns and taken to hospital
Quick response: Firefighters scale the roof of the complex. The fire was extinguished just after 10am
'Exploding glass': Firefighters from the Los Angeles Fire Department responded to a 9.50am call
A spokesman for the actress told People.com that the cause of the fire is 'undetermined' although a firefighter at the scene told TMZ the blaze started on the sofa.
The apartment is located in The Granville Towers complex on Crescent Heights Boulevard, which has been home to many celebrities including Monroe, Mickey Rourke and Portia de Rossi.
One bedroom suites alone command monthly rentals of between $3,000 and $4,000 at the luxurious building.
Famous faces: Twilight star Greene lives in the apartment that caught fire; the Granville Towers complex has been home to many a celebrity including Marilyn Monroe, Mickey Rourke and Portia de Rossi
Gutted: Plumes of smoke billow from the building with firefighters seen tackling the blaze inside
Parked up: Emergency response teams filled the surrounding streets of the building, located on Crescent Heights Boulevard
Fifty-five firefighters worked at the scene to quell the blaze and 10 ambulances were parked up down the street.
Eyewitness Erin Boyle told MailOnline: 'It was completely burnt out, the whole apartment was burnt to a crisp. All the windows were blown out with smoke billowing out of them.
'All of the building had been evacuated and all of the residence were outside. Some looked scared, some were angry.'
A second witness, Sam Nolan, said, described the drama as like a scene from a disaster movie.
'All of a sudden police rushed to close the street, blocking both ends. Then firetrucks started roaring down the street.
‘Three or four of the fire trucks had ladders going up the complex. One going into her apartment, one going onto the roof and one going around the rear.
‘All you could see was black smoke.'
‘All you could see was black smoke.'
Tragic: Ashley holding her dog Theo and left, her other fox terrier Marlo. Only one of the animals survived the blaze
Mr Nola went on: 'Everyone was looking, the neighbours were taking pictures and then a TV crew turned up.
'It was like a disaster film, I thought I’d become part of a Day After Tomorrow.'
Los Angeles Fire Department Inspector Johnson confirmed crews were dispatched at 9:50 am.
'We made an aggressive fire attack. Our team saw smoke and fire coming from the third floor,' he told RadarOnline.
Inspector Johnson added: 'We have reports of two patrons that were burned, so they were treated by the paramedics and sent to the hospital.'
Mystery: It is unclear if Greene’s unnamed boyfriend is Reese Witherspoon’s ex-husband Ryan Phillippe. The pair became the subject of romance rumours this week after being photographed leaving Hollywood’s Vignette Lounge on Wednesday
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